Role of Bisphenol A in Regulation of Arrival of Sexual Maturity and Fertility in Male Albino Rats

Reproductive toxicity during prepubertal and pubertal period causes significant alterations in sexual maturation fertility. Bisphenol A has been associated with decreased sperm production, damaged testicular cells, perturbed hormone levels reduced Its role maturity duration before first successful mating is still elusive. The present study aimed to investigate BPA induced alteration development fertility at critical of peri-adolescence, adolescence adulthood. Male albino rats were administered 5, 25, 50 mg/kg body weight/day (Group II, III IV) for three separate time intervals 42-63, 42-91, 42-105 postnatal days (PND). Body weight measured polynomial regression was applied predict associations between variables. Fertility test observed every 7 interval each dose investigated intervals. Histological observations carried out examine parallels results test. Results parameter compared respective sham control I). consistent decline gain treated groups (p<0.05). Strong relatedness variables evident (R2³0.9). Initial delayed significantly rats. Group IV showed maximum delay mating. indicated interferences various stages spermatogenesis along presence tubular vacuolization, indicative cellular toxicity. Higher doses inflicted more damage, likewise, longer amplified severity adverse activity. administration reproductive male can adversely affect functions leading